Growth performance and antioxidant status of growing rabbits fed on diets supplemented with Eucommia ulmoides leaves

Authors

  • Song Li Taishan Medical University
  • Miaoqing Zhao Shandong Provincial Hospital Affiliated to Shandong University
  • Tingting Jiang Taishan Medical University
  • Wenwen Lv Taishan Medical University
  • Shujuan Gao Veterinary Bureau of Daiyue
  • Yufa Zhou Veterinary Bureau of Daiyue
  • Zengmin Miao Taishan Medical University

DOI:

https://doi.org/10.4995/wrs.2018.7864

Keywords:

EUL, rabbit, growth performance, antioxidant status, heat stress condition

Abstract

The present study evaluated the effect of dietary Eucommia ulmoides leaves (EUL) on growth performance and antioxidant status of growing rabbits under heat stress condition. Four hundred and fifty weaned New Zealand male rabbits (6 wk old) were randomly divided into 3 equal groups (150 rabbits/group) and fed with a basal diet (control, digestible energy (DE): 15.92 MJ/kg and crude protein (CP): 19.24%) or the basal diet supplemented with 1 or 5 g of EUL/kg of diet (EUL1 and EUL5), in which the same quantity of barley meal was replaced. During the 21 d of experiment (43 to 63 d of age), the temperature and relative humidity of the rabbit house ranged from 27.5 to 32.5°C and from 65 to 73%, respectively. We analysed feed intake, growth performance and antioxidant status of growing rabbits. Compared with the control group, at the end of the experimental period, EUL supplementation significantly reduced the average daily feed intake (92.0, 92.8 and 100.7 g/d for EUL1, EUL5 and control, respectively; P<0.05), improved the feed conversion ratio (3.80, 3.81 and 4.59 for EUL1, EUL5 and control, respectively; P<0.05), increased the activities of glutathione peroxidase (+35.5 and +35.0% in plasma and liver of rabbits in EUL5 vs. control group, respectively; P<0.05) and reduced those of malondialdehyde (–12.0 and –46.0% in plasma and liver of rabbits in EUL5 vs. control group, respectively; P<0.05). These results suggest that inclusion of EUL in the diet of growing rabbits improved the growth performance and antioxidant status in growing rabbits.

Downloads

Download data is not yet available.

Author Biographies

Song Li, Taishan Medical University

College of Basic Medicine

Miaoqing Zhao, Shandong Provincial Hospital Affiliated to Shandong University

Department of Pathology

Tingting Jiang, Taishan Medical University

College of Life Sciences

Wenwen Lv, Taishan Medical University

College of Life Sciences

Shujuan Gao, Veterinary Bureau of Daiyue

Center for Disease Control

Yufa Zhou, Veterinary Bureau of Daiyue

Center for Disease Control

Zengmin Miao, Taishan Medical University

College of Life Sciences

References

Blokhina O., Virolainen E., Fagerstedt K.V. 2003. Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann. Bot., 91: 179-194. https://doi.org/10.1093/aob/mcf118

Bollengier-Lee S., Mitchell M.A., Utomo D.B., Williams P.E.V., Whitehead C.C. 1998. Influence of high dietary vitamin E supplementation on egg production and plasma characteristics in hens subjected to heat stress. Br. Poult. Sci., 39: 106-112. https://doi.org/10.1080/00071669889466

Cervera C., Carmona J.F. 2010. Nutrition and the climatic environment. In nutrition of the rabbit (eds. C. de Blas, J. Wiseman, D. Allain, E. Blas and R. Carabaño), CABI, Wallingford, 267-284. https://doi.org/10.1079/9781845936693.0267

Chen Z., He J., Tang D., Shi Q., Li Q. 2004. Nutrient distribution and uptake characteristics in Fucommia ulmoides Oliv. Plant. J. Northwest. For. Coll., 19:15-17.

De Blas C., Mateos G.G. 1998. Feed Formulation. In: de Blas, C., Wiseman, J. (Eds.), The Nutrition of the Rabbit. CABI Publishing, New York, NY, USA, 241-253.

Deyama T., Nishibe S., Nakazawa Y. 2001. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharm. Sin., 22: 1057-1070.

El-Desoky N.I., Hashem N.M., Elkomy A., Abo-Elezz Z.R. 2017. Physiological response and semen quality of rabbit bucks supplemented with Moringa leaves ethanolic extract during summer season. Animal, 14: 1-9. https://doi.org/10.1017/S1751731117000088

El-Gindy Y.M., Zeweil H.S. 2017. Effects of parsley supplementation on the seminal quality, blood lipid profile and oxidant status of young and old male rabbits. World Rabbit Sci, 25: 215-223. https://doi.org/10.4995/wrs.2017.6532

Freeman B.A., Crapo J.D. 1982. Biology of disease: free radicals and tissue injury. Lab Invest., 47: 412-426.

Halliwell B.E., Gutteridge J.M.C. 1989. Lipid Peroxidation: a Radical Chain Reaction, Free Radical in Biology and Medicine, 2nd ed. Oxford University Press, New York, NY, 188-218.

Hassan F.A., Mahrose K.M., Basyony M.M. 2016. Effects of grape seed extract as a natural antioxidant on growth performance, carcass characteristics and antioxidant status of rabbits during heat stress. Arch. Anim. Nutr., 70: 141-154. https://doi.org/10.1080/1745039X.2016.1139609

Hayashi K., NagaY., Ohtsuka A., TomTa Y. 1994. Effect of dietary corticosterone and trilostane on growth and skeletal muscle protein turnover in broiler cockerels. Br. Poult. Sci., 35:789- 798. https://doi.org/10.1080/00071669408417743

Hsieh C.L., Yen G.C. 2000. Antioxidant actions of Duzhong (Eucommia ulmoides Oliv.) toward oxidative damage in biomolecules. Life Sci., 66: 1387-1400. https://doi.org/10.1016/S0024-3205(00)00450-1

Hung M.Y., Fu T.Y., Shih P.H., Lee C.P., Yen G.C. 2006. Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats. Food Chem. Toxicol., 44: 1424-1431. https://doi.org/10.1016/j.fct.2006.03.009

Josephine A., Nithya K., Amudha G., Veena C.K., Preetha S.P., Varalakshmi P. 2008. Role of sulphated polysaccharides from Sargassum wightii in cyclosporine A-induced oxidative liver injury in rats. BMC Pharmacol., 8: 1-9. https://doi.org/10.1186/1471-2210-8-4

Kim G.J., Fiskum G.M., Morgan W.F. 2006. A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability. Cancer Res., 66: 10377-10383. https://doi.org/10.1158/0008-5472.CAN-05-3036

Lee S.D., Kim H.Y., Song Y.M., Jung H.J., Ji S.Y., Jang H.D., Ryu J.W., Park J.C., Moon H.K., Kim I.C. 2009. The effect of Eucommia ulmoides leaf supplementation on the growth performance, blood and meat quality parameters in growing and finishing pigs. Anim. Sci. J., 80: 41-45. https://doi.org/10.1111/j.1740-0929.2008.00593.x

Liu H.W., Dong X.F., Tong J.M., Qi Z. 2010. Alfalfa polysaccharides improve the growth performance and antioxidant status of heat-stressed rabbits. Livest. Sci., 131: 88-93. https://doi.org/10.1016/j.livsci.2010.03.004

Marai I.F.M., Habeeb A.A.M., Gad A.E. 2002. Rabbits’ productive, reproductive and physiological performance traits as affected by heat stress: a review. Livest. Prod. Sci., 78: 71-90. https://doi.org/10.1016/S0301-6226(02)00091-X

Masella R., Benedetto R.D., Varì R., Filesi C., Giovannini C. 2005. Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J. Nutr. Biochem., 16: 577-586. https://doi.org/10.1016/j.jnutbio.2005.05.013

Payne R.L., Southern L.L. 2005. Changes in glutathione peroxidase and tissue selenium concentrations of broiler after consuming a diet adequate in selenium. Poult. Sci., 84: 1268-1276. https://doi.org/10.1093/ps/84.8.1268

Pla M., Fernández-Carmona J., Blas E., Cervera C. 1994. Growth and some carcass traits of adult rabbits under high ambient temperature. World Rabbit Sci., 2: 147-151.

Sahin K., Kucuk O. 2003. Heat stress and dietary vitamin supplementation of poultry diets. Nutr. Abstr. Rev. Ser. B, 73: 41-50.

Takamura C., Hirata T., Ueda T., Ono M., Miyashita H., Ikeda T., Nohara T. 2007. Iridoids from the green leaves of Eucommia ulmoides. J. Nat. Prod., 70: 1312-1316. https://doi.org/10.1021/np0780046

Tuzcu M., Sahin N., Karatepe M., Cikim G., Kilinc U., Sahin K. 2008. Epigallocatechin-3-gallate supplementation can improve antioxidant status in stressed quail. Br. Poult. Sci., 49: 643-648. https://doi.org/10.1080/00071660802298336

Villamide M.J., Carabaño R., Maertens L., Pascual J., Gidenne T., Falcão-E-Cunha L., Xiccato G. 2009. Prediction of the nutritional value of European compound feeds for rabbits by chemical components and in vitro analysis. Anim. Feed Sci. Technol., 150: 283-294. https://doi.org/10.1016/j.anifeedsci.2008.09.007

Wang H.L., Chen W.W., Tian Y. 2003. Effects of Eucommia ulmoides oliver leaf on broiler chicken. Guangdong Feeding, 12: 13-14.

Wang Y.Z., Xu C.L., An Z.H., Liu J.X., Feng J. 2008. Effect of dietary bovine lactoferrin on performance and antioxidant status of piglets. Anim. Feed Sci. Technol., 140: 326-336. https://doi.org/10.1016/j.anifeedsci.2007.02.006

Yen G.C., Hsieh C.L. 2000. Reactive oxygen species scavenging activity of Du-zhong (Eucommia ulmoides Oliv.) and its active compounds. J. Agric. Food Chem., 48: 3431-3436. https://doi.org/10.1021/jf000150t

Young H.S., Park J.C., Park H.J., Lee J.H., Choi J.S. 1991. Phenolic compounds of the leaves of Eucommia ulmoides. Arch. Pharm. Res., 14: 114-117. https://doi.org/10.1007/BF02892014

Zhang Q., Su Y.Q., Yang F.X., Peng J.N., Li X.H., Sun R.C. 2007. Antioxidative activity of water extracts from leaf, male flower, raw cortex and fruit of Eucommia ulmoides Oliv. Forest Prod. J., 57: 74-78.

Zhang Q., Su Y., Zhang J. 2013. Seasonal difference in antioxidant capacity and active compounds contents of Eucommia ulmoides oliver leaf. Molecules, 18: 1857-1868. https://doi.org/10.3390/molecules18021857

Zhao R., Shen G.X. 2005. Functional modulation of antioxidant enzymes in vascular endothelial cells by glycated LDL. Atherosclerosis, 179: 277-284. https://doi.org/10.1016/j.atherosclerosis.2004.11.013

Downloads

Published

2018-03-28

Issue

Section

Nutrition