Short communication: massive mortality in rabbits by maduramicin poisoning

 P.E. Martino, E. Parrado, R. Sanguinetti, C. Espinoza, R. Debenedetti, N.M. Di Benedetto, C. Cisterna, P. Gómez

Abstract

A spontaneous outbreak of maduramicin intoxication in domestic rabbits (Oryctolagus cuniculus) is reported. It is believed that maduramicin incorporated as a coccidiostat into poultry pellet fed to rabbits was the cause, as up to 2.01 ppm was found in the samples and cardiopulmonary clinical signs in most of the rabbits was the common pattern. Findings here were consistent with the classic indications observed in ionophore toxicosis in different species, but little is known about the toxicity of maduramicin in rabbits.

Keywords

maduramicin; ionophore toxicosis; rabbit

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References

Arts, H.T. 1991. Poisoning due to an ionophore anticoccidial agent in a commercial rabbit breeding farm. Tijdschr. Diergeneeskd. 116: 504-507.

Bastianello S.S., Fourie N., Prozesky L., Nel P. 1995. Cardiomyopathy of ruminants induced by the litter of poultry fed on rations containing the ionophore antibiotic, maduramicin. Onderstepoort J. Vet. Res., 62: 5-18.

De Jong J, B., Stoisser K., Wagner M., Tomassen J., Driessen J., Hofmann P., Putzka H. 2004. Determination of maduramicin in feedingstuffs and premixtures by liquid chromatography. J.AOAC Int., 87: 1033-1041.

Hamilton G.A., Rutven A.D., Findlay E., Hunter K., Lidsay D. 1981. Wildlife deaths resulting from misuse of agricultural chemicals. Biol. Conserv., 21: 315-326.

Martino P.E., Samus S., Piscopo M., Risso M., Lacchini R. 2000. Randomised sanitary status of Argentinean rabbitry. World Rabbit Sci., 8: 145-147.

Novilla M.N. 1992. The veterinary importance of the toxic syndrome induced by ionophores. Vet. Hum.Toxicol., 34: 66-

Oehme F.W., Pickrell J.A. 1999. An analysis of the chronic oral toxicity of polyether ionophore antibiotics in animals. Vet. Hum. Toxicol., 41: 251-257.

Polozowski A. 1993. Coccidiosis of rabbits. Wiad. Parazytol., 39: 13- 28.

Salles M.S., Lombardo de Barros C.S., Barros S. 1994. Ionophore antibiotic (narasin) poisoning in rabbits. Vet. Hum. Toxicol. 36: 437-444.

Shlosberg A., Perl S., Harmelin A., Hanji V., Bellaiche M. 1997. Acute maduramicin toxicity in calves. Vet. Rec. 140: 643-646.

Sharma N., Bhalla A., Varma S., Jain S., Singh S. 2005. Toxicity of maduramicin. Emerg. Med. J. 22: 880-882.

Uko O.J., Ataja A.M., Tanko H.B. 2000. Weight gain, haematology and blood chemistry of rabbits fed cereal offals. Sokoto J. Vet. Sci., 2: 18-26.

Weschler N.B. 1983. Blood collection techniques and normal values for ferrets, rabbits, and rodents: a review. Vet. Med. N.Am./Small Anim. Clin. 78: 713-713.

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 Universitat Politècnica de València

 

Official journal of the World Rabbit Science Association (WRSA)

 

e-ISSN: 1989-8886     ISSN: 1257-5011   https://doi.org/10.4995/wrs