A note on linkage between the Angora and fgf5 genes in rabbits.

 P. Mulsant, H. De Rochambeau, R.G. Thébault
DOI: https://doi.org/10.4995/wrs.2004.585

Abstract

The angora mutation in mice corresponds to a large deletion in the fgf5 (fibroblast growth factor 5) exon 1. Two pairs of primers were chosen in the human fgf5 coding sequence in order to amplify two fragments of the rabbit gene. One biallelic polymorphism was demonstrated in each fragment. The four alleles were cloned and sequenced. A random sample of unrelated angora (n=17) and wild-type control animals (n=15) were analysed for both polymorphisms. The observed haplotype frequencies show a clear separation between the two populations. Informative families were created by backcrossing to measure linkage between the angora and fgf5 loci. No recombinant was observed between them, in 56 meiosis, proving a tight linkage between both genes.

Keywords

rabbit; angora gene; mice; fibroblast growth factor 5 gene

Full Text:

PDF

Abstract Views

753
Metrics Loading ...

Metrics powered by PLOS ALM


Bookmark and Share

 

Cited-By (articles included in Crossref)

This journal is a Crossref Cited-by Linking member. This list shows the references that citing the article automatically, if there are. For more information about the system please visit Crossref site

1. Cdrom Archive: A Gateway to Study Camel Phenotypes
Hasan Alhaddad, Bader H. Alhajeri
Frontiers in Genetics  vol: 10  year: 2019  
doi: 10.3389/fgene.2019.00048



 

 Universitat Politècnica de València

 

Official journal of the World Rabbit Science Association (WRSA)

 

e-ISSN: 1989-8886     ISSN: 1257-5011   https://doi.org/10.4995/wrs