Study of failures in a rabbit line selected for growth rate

C. Naturil-Alfonso, R. Lavara, P. Millán, P.G. Rebollar, J.S. Vicente, F. Marco-Jiménez

Abstract

Selection for growth rate is negatively related with reproductive fitness. The aim of this work was to analyse the causes of fertility failure in rabbit does selected for growth rate and characterised for reproductive deficiencies (line R). In the experiment, 82 does were divided into 2 groups: naturally mated (NM) and artificially inseminated (AI), to relate luteinizing hormone (LH) concentration with ovulation induction and pregnancy rate by laparoscopic determination. Additionally, in 38 of these females ovulation rate and metabolites determination (leptin, NEFA, BOHB and glucose) were analysed and perirenal fat thickness measurement and live body weight (LBW) determined. The results showed that all ovulated does (both NM and AI) presented higher concentrations of LH than non-ovulated females. In addition, non-ovulated females showed high levels of leptin and BOHB, as well as LBW. Females from line R have an inherit reduced fertility due to ovulation failure as a consequence of a reduction in LH release, which could be explained by a heavier body weight and higher leptin concentrations.


Keywords

ovulation failure; growth rate; LH; mating

Full Text:

PDF

References

Balasubramanian P., Jagannathan L., Subramanian M., Gilbreath E.T., MohanKumar P.S., MohanKumar S.M.J. 2012. High fat diet affects reproductive functions in female diet-induced obese and dietary resistant rats. J. Neurondocrinol., 24: 748-755. doi:10.1111/j.1365-2826.2011.02276.x

Bakker J., Baum M.J. 2000. Neuroendocrine regulation of GnRH release in induced ovulators. Front. Neuroendocrin., 21: 220-262. doi:10.1006/frne.2000.0198

Brecchia G., Bonanno A., Galeati G., Federici C., Maranesi M., Gobbetti A., Zerani M., Boiti C. 2006. Hormonal and metabolic adaptation to fasting: Effects on the hypothalamic-pituitaryovarian axis and reproductive performance of rabbit does. Dom. Anim. Endocrinol., 31: 105-122. doi:10.1016/j.domaniend.2005.09.006

Brien F.D., Sharp G.L., Hill W.G., Robertson A. 1984. Effects of selection on growth, body composition and food intake in mice. II. Correlated responses in reproduction. Genet. Res., 44: 73-85. doi:10.1017/S0016672300026252

Cano P., Jiménez-Ortega V., Larrad A., Reyes Tosco C.F., Cardinali D.P., Esquifina A.I. 2008. Effect of a high-fat diet on 24-h pattern of circulating levels of prolactin, luteinising hormone, testosterone, corticosterone, thyroid-stimulating hormone and glucose, and pineal melatonin content, in rats. Endocrine, 33: 118-125. doi:10.1007/s12020-008-9066-x

Cardinali R., Dal Bosco A., Bonanno A., Di Grioli A., Rebollar P.G., Lorenzo P.L., Castellini C. 2008. Connection between body condition score, chemical characteristics of body and reproductive traits of rabbit does. Livest. Sci., 116: 209-215.

doi:10.1016/j.livsci.2007.10.004

Chen P., Baas T.J., Mabry J.W., Koehler K.J. 2003. Genetic correlations between lean growth and litter traits in U.S. Yorkshire, Duroc, Hampshire, and Landrace pigs. J. Anim. Sci., 81: 1700-1705.

Cordier A.G., Léveillé P., Dupont C., Tarrade A., Picone O., Larcher T., Dahirel M., Poumerol E., Mandon-Pepin B., Lévy R., Chavatte-Palmer P. 2013. Dietary lipid and cholesterol induce ovarian dysfunction and abnormal LH response to stimulation in rabbits. Plos one, 8: e63101. doi:10.1371/journal.pone.0063101

Dal Bosco A., Rebollar P.G., Boiti C., Zerani M., Castellini C. 2011. Ovulation induction in rabbits does: Current knowledge and perspectives. Anim. Reprod. Sci., 129: 106-117. doi:10.1016/j.anireprosci.2011.11.007

Dall’Aglio C., Millán P., Maranesi M., Rebollar P.G., Brecchia G., Zerani M., Gobbetti A., Gonzalez-Mariscal G., Boiti C. 2013. Expression of the cannabionoid receptor type 1 in the pituitary of rabbits and its role in the control of LH secretion. Dom. Anim. Endocrinol., 45: 171-179. doi:10.1016/j.domaniend.2013.08.004

Dufy-Barbe L., Franchimot P., Faure G.M.A. 1973. Time-courses of the LH and FSH release after mating in the female rabbit. Endocrinology, 92: 1318-1321. doi:10.1210/endo-92-5-1318

Duggal P.S., Van der Hoek K.H., Milner C.R., Ryan N.K., Amstrong D.T., Magoffin D.A., Norman R.J. 2000. The in vivo and in vitro effects of exogenous leptin on ovulation in the rat. Endocrinology, 141: 1971-1976. doi:10.1210/endo.141.6.7509

Eisen E.J., Hanrahan J.P., Legates J.E. 1973. Effects of population size and selection intensity on correlated responses to selection for postweaning gain in mice. Genetics, 74: 157- 170.

Estany J., Camacho J., Baselga M., Blasco A. 1992. Selection response of growth rate in rabbits for meat production. Genet. Sel. Evol., 24: 527-537. doi:10.1186/1297-9686-24-6-527

Fisher B., Chavatte-Palmer P., Viebahn C., Navarrete-Santos A., Duranthon V. 2012. Rabbit as a reproductive model for human health. Reproduction, 144: 1-10.

doi:10.1530/REP-12-0091

Gadsby J.E., Keyes P.L., Bill C.H. 1983. Control of corpus luteum function in the pregnant rabbit: role of estrogen and lack of a direct luteotropic role of the placenta. Endocrinology, 119: 2255-2262. doi:10.1210/endo-113-6-2255

Gomez E.A., Rafel O., Ramon J. 1998. Genetic relationships between growth and litter size traits at first parity in a specialized dam line. In Proc.: 6th W.C.G.A.L.P., Vol. XXV, 552-555.

Gómez E.A., Baselga M., Rafel O., García M.L., Ramón J. 1999. Selection, diffusion and performances of six Spanish lines of meat rabbit. Cahiers Options Méditerranéennes, 41: 147-152.

Haggarty P. 2002. Placental regulation of fatty acid delivery and its effect on fetal growth- a review. Placenta, 23: S28-38. doi:10.1053/plac.2002.0791

Harano Y., Ohtsuki M., Ida M., Kojima H., Harada M., Okanishi T., Kashiwagi A., Ochi Y., Uno S., Shigeta Y. 1985. Direct automated assay method for serum or urine levels of ketone bodies. Clin. Chim. Acta, 151: 177-183. doi:10.1016/0009-8981(85)90321-3

Hendrickse W., Stammers J.P., Hull D. 1985. The transfer of free fatty acids across the human placenta. Br. J. Obstet. Gynaecol., 92: 945-952. doi:10.1111/j.1471-0528.1985.tb03075.x

Jones E.F., Bain J.B., Odell W.D. 1976. Postcoital luteinizing hormone release in male and female rabbits as determine by radioimmunoassay. Fertil. Steril., 27: 848-852.

Kiani. 2012. Temporal changes in plasma concentration of leptin, IGF-I, insulin and metabolites under extended fasting and re-feeding conditions in growing lambs. Int Journal of Endocrinology and metabolism, 11: 34-40. doi:10.5812/ijem.6529

Kuhlers D.L., Jungst S.B. 1992. Correlated responses in reproductive and carcass traits to selection for 200-day weight in Duroc swine. J. Anim, Sci., 70: 2707-2713.

Mgheni M., Christensen K. 1985. Selection experiment on growth and litter size in rabbits: II. Two-way selection response for body weight at 112 days. Acta Agric. Scand., 35: 278-286. doi:10.1080/00015128509435784

Mehaisen G.M.K., Vicente J.S., Lavara R. 2004. In vivo embryo recovery rate by laparoscopic technique from rabbit does selected for growth rate. Reprod. Dom. Anim., 39: 347-351. doi:10.1111/j.1439-0531.2004.00526.x

Meunier M., Hulot F., Poirier J.C., Torres S. 1983. A comparison of ovulatory gonadotropic surge in two rabbit strains: no evidence for a relationship between LH or FSH surge and factors of prolificacy. Reprod. Nutr. Dévelop., 23: 709-715. doi:10.1051/rnd:19830504

Montoudis A., Simoneau L., Brisette L., Forest J.C., Savard R., Lafond J. 1999. Impact of cholesterol enriched diet on maternal and fetal plasma lipids and fetal deposition in pregnant rabbits. Life Sci., 64: 2439-2450. doi:10.1016/S0024-3205(99)00201-5

Moschos S., Chan J.L., Mantzoros C.S. 2002. Leptin and reproduction: a review. Fertil. Steril., 77: 433-444. doi:10.1016/S0015-0282(01)03010-2

Muelas R., Cano P., García M.L., Esquifino A., Argente M.J. 2008. Influence of FSH, LH and prolactin on the components of litter size in rabbit does. 9th World Rabbit Congress, 10-13 June, 2008. Verone, Italy.

Opsina P.A., Nydam D.V., Stokol T., Overton T.R. 2010. Associations of elevated nonesterified fatty acids and β-hydroxybutyrate concentrations with early lactation reproductive performance and milk production in transition airy cattle in the northeaster United States. J. Dairy Sci., 93: 1596-1603. doi:10.3168/jds.2009-2852

Pascual J.J., Castella F., Cervera C., Blas E., Fernández-Carmona J. 2000. The use of ultrasound measurement of perirenal fat thickness to estimate changes in body condition of young female rabbits. Anim. Sci., 70: 435-442.

Pasquali R., Casimirri F. 1993. The impact of obesity in hyperandrogenism and polycystic ovary syndrome in premenopausal women. Clin. Edocrinol., 39: 1-16. doi:10.1111/j.1365-2265.1993.tb01744.x

Pieper D.R., Richards J.S., Marshall J.C. 1981. Ovarian gonadotropin-releasing hormone (GnRH) receptors: characterization, distribution and induction by GnRH. Endocrinology, 108: 1148-1155. doi:10.1210/endo-108-4-1148

Picone O., Laigre P., Fortun-Lamothe L., Archilla C., Peynot N., Ponter A.A., Berthelot V., Cordier A.G., Duranthon V., Chavatte-Palmer P. 2011. Hyperlipidic hypercholesterolemic diet in prepubertal rabbits affects gene expression in the embryo, restricts fetal growth and increases offspring susceptibility to obesity. Theriogenology, 75: 287-299. doi:10.1016/j.theriogenology.2010.08.015

Quennell J.H., Howell C.S., Roa J., Augustine R.A., Grattan D.R., Anderson G.M. 2011. Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology, 152: 1541-1550. doi:10.1210/en.2010-1100

Quintela L.A., Peña A.I., Vega M.D., Gullón J., Prieto M.C., Barrio M., Becerra J.J., Maseda F., Herradón P.G. 2004. Ovulation induction in rabbit does submitted to artificial insemination by adding busereline to the seminal dose. Reprod. Nutr. Dev., 44: 79-88. doi:10.1051/rnd:2004015

Ragab M., Baselga M. 2010. Inbreeding effect on reproductive traits in four maternal lines of rabbits. In Proc: 9th World Congress on Genetics Applied to Livestock Production, 1-6 August, 2010. Leipzig, Germany. p. ID083

Rebollar P.G., Dal Bosco A., Millán P., Cardinali R., Brecchia G., Sylla L., Lorenzo P.L., Castellini C. 2012. Ovulating induction in rabbit does: The pituitary and ovarian responses. Tehriogenology, 77: 292-298. doi:10.1016/j.theriogenology.2011.07.041

Sánchez J.P., de la Fuente L.F., Rosell J.M. 2012. Health and body condition of lactating females on rabbit farms. J. Anim. Sci., 90: 2353-2361. doi:10.2527/jas.2011-4065

Seke H., Nowicki M., Kosacka J., Schröder T., Klöting N., Blüher M., Kallendrusch S., Spanel-Borowski K. 2012. Leptin-deficient (ob/ob) mouse ovaries show fatty degeneration, enhanced apoptosis and decreased expression of steroifogenic acute regulatory enzyme. Int. J. Obes. (Lond), 36: 1047-1053. doi:10.1038/ijo.2011.220

Sjoblom C., Roberts C.T., Wikland M., Roberston S.A. 2005. Granulocyte-Macrophage colony-stimulating factor alleviates adverse consequences embryo culture on fetal growth trajectory and placental morphogenesis. Endocrinology, 146: 2142-2153. doi:10.1210/en.2004-1260

Tortoriello D.V., McMinn J., Chua S.C. 2004. Dietary-induced obesity and hypotalamic infertility in female DBA/2J mice. Endocrinology, 145: 1238-1247. doi:10.1210/en.2003-1406

Uenoyama Y., Tsukamura H., Kinoshita M., Yamada S., Iwata K., Pheng V., Sajapitak S., Sakakibara M., Ohtaki T., Matsumoto H., Maeda K.I. 2008. Oestrogen-dependent stimulation of luteinizing hormone release by galanin-like peptide in female rats. J. Neuroendocrinol., 20: 626-631. doi:10.1111/j.1365-2826.2008.01703.x

Vicente J.S., Viudes-de-Catro M.P., García M.L., Baselga M. 2003. Effect of rabbit line on a program of cryopreserved embryos by vitrification. Reprod. Nutr. Develop., 43: 137-143. doi:10.1051/rnd:2003011

Vicente J.S., Llobat L., Viudes-de-Castro M.P., Lavara R., Baselga M., Marco-Jiménez F. 2012. Gestational losses in a rabbit line selected for growth rate. Theriogenology, 77: 81-88. doi:10.1016/j.theriogenology.2011.07.019

Vicente J.S., Llobat L., Jiménez-Trigos E., Lavara R., Marco- Jiménez F. 2013. Effect of embryonic and maternal genotype on embryo and foetal survival in rabbit. Reprod. Dom. Anim., 48: 402-406. doi:10.1111/rda.12087

Viudes-de-Castro M.P., Garcia-Ximénez F., Vicente J.S. 1995. Embryo recovery from eliminating does of three rabbit strain for an embryo bank. Invest. Agr. Prod. Sanid. Anim., 10: 145- 152.

Viudes-de-Castro M.P., Vicente J.S. 1997. Effect of sperm count on the fertility and prolificity rates of meat rabbits. Anim. Reprod. Sci., 46: 313-319.

doi:10.1016/S0378-4320(96)01628-4

Abstract Views

4316
Metrics Loading ...

Metrics powered by PLOS ALM


 

Cited-By (articles included in Crossref)

This journal is a Crossref Cited-by Linking member. This list shows the references that citing the article automatically, if there are. For more information about the system please visit Crossref site

1. Long-term implications of feed energy source in different genetic types of reproductive rabbit females: I. Resource acquisition and allocation
A. Arnau-Bonachera, C. Cervera, E. Blas, T. Larsen, E. Martínez-Paredes, L. Ródenas, J.J. Pascual
Animal  vol: 12  issue: 9  first page: 1867  year: 2018  
doi: 10.1017/S1751731117003287



 

 Universitat Politècnica de València

 

Official journal of the World Rabbit Science Association (WRSA)

 

e-ISSN: 1989-8886     ISSN: 1257-5011   https://doi.org/10.4995/wrs