Changes in plasma progesterone and estradiol during natural prostaglandin F2a-induced parturition in the rabbit.

 P.G. Rebollar, J.M.R. Alvariño, J.C. Illera, G. Silvan, P. Lorenzo


Toe influence of administration of natural prostaglandin F2a (PgF) on plasma progesterone (P4) and estradiol-1713 (E2) levels during the last days of pregnancy (days 29-32) was studied in 13 doe rabbits of the California x New Zealand White breed. Animals were allocated to receive either a single intramuscular injection of 800 or 1200µg of natural PgF on day 29 of pregnancy at 10 h (treated groups) or no injection (control group). All does treated with PgF kindled within 60 h after injection, whereas the variation in birth time in control group was greater (79.2 ± 8.9 h). No influence of the prostaglandin treatment on mean plasma estradiol (5.2 pg/ml) and both litter size and born dead (7.2 ± 0.7 and 0.4 ± 0.6, respectively) was observed. A significant fall in progesterone concentration was defected in treated animals at 20 h on day 29 compared with control group (3.17 ± 0.22 and 3.47 ± 0.32 vs. 6.7 ± 1.4 ng/ml; P<0.05). Our results suggest that the induction of parturition with natural PgF has similar effects on plasma P4 levels and in synchronization of parturitions to synthetic analogues, although the dose administered is greater.

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 Universitat Politècnica de València

Official journal of the World Rabbit Science Association (WRSA)

e-ISSN: 1989-8886     ISSN: 1257-5011