Influence of two iso-energetic diets (starch vs fat) on experimental colibacillosis (epec) and iota-enterotoxaemia in early weaned rabbits.

 J. E. Peeters, R. Orsenigo, L. Maertens, D. Gallazzi, M. Colin

Abstract

Rabbits weaned at 32 days of age were fed one of two iso­energetic (10.6 MJ ADE/kg) and iso-protein (17 %) feeds ad libitum: feed S with 25.8 % starch, 3.2 % fat and 16.2 % acid detergent fibre (ADF) and feed F with 13.1 % starch, 6. 7 % fat and 17.9 % ADF. Both groups were inoculated orally with a toxinogenic Clostridium spiroforme strain NCTC 11493 and/or with a moderately enteropathogenic Escherichia coli (EPEC) strain belonging to sero/biotype 0132/2+. The results suggest that colibacillosis favours iota-enterotoxaemia and vice-versa. Also the feed shows a distinct influence. Feed S favoured iota-enterotoxaemia. The effect was most pronounced in rabbits suffering from simultaneous EPEC nfection. On the other hand the same feed inhibited saprophytic E. co/i-proliferation. In case of experimental EPEC infection, feed S did not inhibit the huge faecal E. coli output, nor the associated diarrhoea and mortality. Yet, histological lesions were less pronounced in the S-group. Moreover, entero-adherent EPEC were still present in one rabbit out of five in group F 28 days p.i., while they were not detectad in any of the S-rabbits. In case of mixed infection (C. spiroforme + EPEC), mortality was lower in group S (2/10) than in group F (5/10). So, feed F might favour colibacillosis. lt was hypothesised that feeds of this type may contribute to the persistence of healthy carriers of enteropathogenic E. coli.


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References

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