Changes of oxidant-antioxidant parameters in small intestines from rabbits infected with E. intestinalis and E. magna

Authors

  • Yun Xiao Zhou Jiangxi Agricultural University
  • Xu Yuan Jiangxi Agricultural University
  • Xiao Fen Hu Jiangxi Agricultural University
  • Shan Shan Yang Jiangxi Agricultural University
  • Sheng Wei Zhong Jiangxi Agricultural University
  • Ting Yu Yang Jiangxi Agricultural University
  • Guo Tong Zhao Jiangxi Agricultural University
  • Yi Jie Jiang Jiangxi Agricultural University
  • Yong Li Jiangxi Agricultural University

DOI:

https://doi.org/10.4995/wrs.2022.17395

Keywords:

E. magna, E. intestinalis, oxidative stress, oxidant-antioxidant balance, rabbit

Abstract

Rabbit coccidiosis is a very serious disease caused by protozoan parasites of the genus Eimeria, which increases the production rate of free radicals, especially reactive oxygen species. When the generation of free radicals exceeds the scavenging capacity of the body’s antioxidant system, the oxidant-antioxidant balance is broken, resulting in oxidative stress. This study was designed to investigate the effect on the oxidant-antioxidant status of rabbits infected with E. intestinalis and E. magna. To this end, eighteen 30-d-old weaned rabbits were randomly allocated into three groups as follows: the E. intestinalis infection group with 3×103 sporulated oocysts of E. intestinalis, the E. magna infection group with 20×103 sporulated oocysts of E. magna, and the uninfected control group. We measured the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC) and the contents of malondialdehyde (MDA) in rabbits’ small intestinal tissues (duodenum, jejunum and ileum) of the three groups
on day 8. The results showed that CAT activity and MDA levels significantly increased, while the activities of SOD, GSH-Px and T-AOC decreased after E. intestinalis and E. magna infection. Besides, the jejunum and ileum were particularly damaged in the rabbits. It is concluded that the pathological oxidative stress occurs during the E. intestinalis and E. magna infection process and the body’s oxidant-antioxidant balance is disrupted.

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Author Biographies

Yun Xiao Zhou, Jiangxi Agricultural University

College of Animal Science and Technology

Xu Yuan, Jiangxi Agricultural University

College of Animal Science and Technology

Xiao Fen Hu, Jiangxi Agricultural University

College of Animal Science and Technology

Shan Shan Yang, Jiangxi Agricultural University

College of Animal Science and Technology

Sheng Wei Zhong, Jiangxi Agricultural University

College of Animal Science and Technology

Ting Yu Yang, Jiangxi Agricultural University

College of Animal Science and Technology

Guo Tong Zhao, Jiangxi Agricultural University

College of Animal Science and Technology

Yi Jie Jiang, Jiangxi Agricultural University

College of Animal Science and Technology

Yong Li, Jiangxi Agricultural University

College of Animal Science and Technology

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Published

2022-12-29

Issue

Vol. 30 No. 4 (2022)

Section

Pathology

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Copyright (c) 2022 Yun Xiao Zhou, Xu Yuan, Xiao Fen Hu, Shan Shan Yang, Sheng Wei Zhong, Ting Yu Yang, Guo Tong Zhao, Yi Jie Jiang, Yong Li

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