Normal values of haematological and some biochemical parameters in serum and urine of New Zealand White rabbits

Cumali Özkan, Abdullah Kaya, Yakup Akgül


The purpose of the present study was to define the normal haematologic values and some biochemical parameters in serum and in urine in both male and female New Zealand white rabbits and to determine the effect of gender on these parameters. Blood and urine samples from a total of 40 New Zealand white rabbits were investigated. The haematologic parameters were determined in whole blood samples, while serum and urine (urine protein, glucose, creatinine, urea, GGT, nitrite, Na, K, Cl, creatinine clearance) biochemical parameters were determined in serum and urine samples. Normal values of these parameters were determined and statistical comparisons between male and female animals performed. No statistically significant differences were found between male and female animals for the parameters analysed except HCT, HGB, granulocyte %, L/M and serum K concentration. As a result, it was judged that defining the normal values of given haematological factors and serum and urine biochemical parameters in this study in New Zealand white rabbits would be helpful for both clinicians and researchers.


biochemical parameters; haematological parameters; normal values; serum; urine; New Zealand rabbit

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Archetti I., Tittarelli C., Cerioli M., Brivio R., Grilli G., Lavazza A. 2008. Serum chemistry and hematology values in commercial rabbits: preliminary data from industrial farms in northern Italy. 9th World Rabbit Congress–June 10-13, Verona–Italy, 1147-1151.

Cetin N., Bilgili A., Eraslan G., Koy A. 2004. Effect of fluoride application on some blood parameters in rabbits. Erciyes University Journal of Health Sciences., 13 (2): 46-50.

Chineke C. A., Ologun A. G., Ikeobi C. O. N. 2006. Haematological parameters in rabbit breeds and crosses in humid tropics. Pakistan Journal of Biological Sciences., 9 (11): 2102-2106.

Elmas M., Yazar E., Uney K., Karabacak A. 2006. Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits. Vet Res Commun., 30: 73-81.

Fuentes G. C., Newgren J. 2008. Physiology and clinical pathology of laboratory New Zealand White Rabbits housed individually and in groups. J Am Assoc Anim Sci., 47 (2): 35-38.

Haghjooyjavanmard S., Nematbakhsh M., Soleimani M. 2009. The effect of hypercholesterolemia on serum vascular endothelial growth factor and nitrite concentrations in early stage of atherosclerosis in rabbits. Pakistan Journal of Nutrition., 8 (1): 86-89.

Hewitt C. D., Innes D. J., Savory J., Wills M. R. 1989. Normal biochemical and hematological values in New Zealand White Rabbits. Clin Chem, 35 (8): 1777-1779.

Jacobson H. A., Kırkpatrivk R. L., McGinnes B. S. 1978. Disease and physiologic characteristics of two cottontail populations in Virginia. Wildlife Monograph., 60: 5-53.

Jeklova E., Leva L., Knotigova P., Faldyna M. 2009. Age-related changes in selected haematology parameteres in rabbits. Res Vet Sci, 86: 525-528.

Jenkins J. R. 2008. Rabbit diagnostic testing. J Exot Pet Med., 17 (1): 4-15.

Jurcik R., Suvegova K., Hanusova E., Massanyi P., Ryban L., Chrenek P. 2007. Evaluation of haematological, biochemical and histopathological parameters of transgenic rabbits. J Vet Med A., 54: 527-531.

Kaneko J. J., Harvey J. W., Bruss M. L. 1997. Clinical Biochemistry of Domestic Animals, 50. Ed., Academic Press, California-USA.

Lepitzki D. A., Woolf A. 1991. Hematology and serum chemistry of cottontail rabbits of southern illinois. J Wildlife Dis., 27 (4): 643-649.

Melillo A. 2007. Rabbit clinical pathology. Journal of Exotic Pet Medicine, 16 (3): 135-145.

Özkan C. 2009. The effects of nitric oxide donour (L-arginine) and nitric oxide synthase inhibitors (Aminoguanidine, L-NAME) in experimentally induced nephrotoxicity in rabbits, University of Yuzuncu Yil Institute of Health Science Department of Internal Diseases, Ph.D Thesis, Van, TURKEY.

Silva T. D. O., Kreutz L. C., Barcellos L. J. G., Borella J., Soso A. B., Souza C. 2005. Reference values for chincchilla (Chinchilla laniger) blood cells and serum biochemical parameters. Ciencia Rural., 35 (3): 602-606.

Tavares F. L., Sousa-e-Silva M. C., Santoro M. L., Barbaro K. C., Rebecchi I. M. M., Sano Martins I. S. 2004. Changes in hematological, hemostatic and biochemical parameters induced experimentally in rabbits by loxosceles gaucho spider venom. Human&Experimental Toxicology., 23: 477-486.

Türkmen M., Kavukçu S., İşlekel H., Sarioğlu S., Akhunlar H., Gökden N., Güre A. 1997. Urinary N-acetyl-β-D-glucosaminidase activity in rabbits with experimental hypercalciuria. Pediatr Nephrol., 11: 481-484.

Wicher V., Wicher K., Gruhn R., Pragay D. A., Durham S., Gould M. C. 1984. Biochemical, hematologic, and histopathologic studies in rabbits intrarectally inseminated. AIDS Research., 1 (5): 299-307.

Yamada S., Ito T., Tamura T., Shiomi M. 2004. Age-related changes in serum/plasma biochemical parameters of WHHLMI rabbits. Exp Anim Tokyo., 53 (2): 159-163.

Yazar E., Çöl R., Konyalıoğlu S., Birdane Y. O., Elmas M., Baş A. L. 2004. Effects of vitamin E and prednisolone on biochemical and haematological parameters in endotoxaemic New Zealand White Rabbits. B Vet I Pulawy., 48: 105-108.

Yu L., Pragay D. A., Chang D., Wicher K. 1979. Biochemical parameters of normal rabbit serum. Clin Biochem., 12 (3): 83-87.

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American Journal of Food Technology  vol: 12  issue: 1  first page: 51  year: 2016  
doi: 10.3923/ajft.2017.51.59

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