Estado del Arte en Neurotecnologías para la Asistencia y la Rehabilitación en España: Tecnologías Fundamentales

Luis J. Barrios, Roberto Hornero, Javier Pérez-Turiel, José L. Pons, Joan Vidal, José M. Azorín

Resumen

Las neurotecnologías son aquellas tecnologías dirigidas al estudio del sistema nervioso o a mejorar su función. Estas tecnologías permiten extender el rango de tratamientos disponibles para la rehabilitación de funciones dañadas y proporcionan nuevas soluciones asistenciales para las funciones perdidas. En este artículo se revisan las neurotecnologías de asistencia y rehabilitación, en trastornos motores principalmente, se introduce una taxonomía que facilita su revisión sistemática, y se proporciona una visión global de los avances logrados en la investigación, desarrollo y aplicación en España de aquellas de sus tecnologías más básicas.


Palabras clave

Neurotecnologías; interfaces cerebro-computador; robótica; procesamiento de señal; estimulación eléctrica; sistemas biomédicos; rehabilitación; tecnologías de asistencia

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Referencias

Alonso, J.F., Mañanas, M.A., Romero, S., Rojas-Martínez, M., Riba, J., 2012. Cross-conditional entropy and coherence analysis on pharmaco-EEG changes induced by alprazolam, Psychopharmacology, 221(3):397-406. DOI: 10.1007/s00213-011-2587-7

Alonso, J.F., Romero, S., Mañanas, M.A., Alcalá, M, Antonijoan, R.M., Giménez, S., 2016. Acute sleep deprivation induces a local increase on brain transfer information in the frontal cortex in a context of widespread decrease, Sensors, 16(4). pii: E540. DOI: 10.3390/s16040540

Angulo Sherman, I. N., Rodríguez Ugarte, M., Iáñez Martínez, E., Azorín Poveda, J. M., 2016. Efecto en la clasificación de imaginación motora a partir del EEG al aplicar tDCS en la corteza motora y el cerebelo. En: Libro de Actas CASEIB 2016. XXXIV Congreso Anual de la Sociedad Española de Ingeniería Biomédica. Valencia, 23 al 25 de noviembre de 2016, 249-252.

Antelis, J.M., Montesano, L., Ramos-Murguialday, A., Birbaumer, N., Minguez, J., 2017. Decoding Upper Limb Movement Attempt from EEG Measurements of the Contralesional Motor Cortex in Chronic Stroke Patients. IEEE Transactions on Biomedical Engineering 64(1), 99 – 111.

Antonakakis, M., Dimitriadis, S.I., Zervakis, M., Micheloyannis, S., Rezaie, R., Babajani-Feremi, A., Zouridakis, G., & Papanicolaou, A.C., 2016. Altered cross-frequency coupling in resting-state MEG after mild traumatic brain injury. Int. Journal of Psychophysiology, 102, 1–11.

Badesa, F. J., Morales, R., Garcia-Aracil, N. M., Sabater, J. M., Zollo, L., Papaleo, E., & Guglielmelli, E. 2016. Dynamic Adaptive System for Robot-Assisted Motion Rehabilitation. IEEE Syst. Journal, 10(3), 984-991.

Barrios, L.J., del Castillo, M.D., Serrano, J.I., Pons, J.L., 2012. A review of fMRI as a tool for enhancing EEG-based brain-machine interfaces. Applied Bionics and Biomechanics 9 (2), 125-133. DOI: 10.3233/ABB2012-0066

Barrios, L.J., Minguillón, J., Perales, F.J., Ron-Angevin, R., Solé-Casals, J., Mañanas, M.A., 2017. Estado del Arte en Neurotecnologías para la Asistencia y la Rehabilitación en España: Tecnologías Auxiliares, Trasferencia Tecnológica y Aplicación Clínica. Revista Iberoamericana de Automática e Informática Industrial RIAI. (En este mismo número).

Barroso, F., Torricelli, D., Bravo-Esteban, E., Taylor, J., Gomez-Soriano, J., Santos, C., Moreno, J., Pons, J.L., Muscle synergies in cycling after incomplete spinal cord injury: correlation with clinical measures of motor function and spasticity, Frontiers in Human Neuroscience, Vol. 9, article 706, 2016. DOI: 10.3389/fnhum.2015.00706.

Benito, J., Kumru, H., Murillo, N., Costa, U., Medina, J., Tormos, J.M., Pascual-Leone, A., Vidal, J., 2012. Motor and gait improvement in patients with incomplete spinal cord injury induced by high-frequency repetitive transcranial magnetic stimulation. Top. Spinal Cord Inj. Rehabil. 18, 106–112. DOI:10.1310/sci1802-106

Borau Duran, A., 2004. Presentation, development and validation of Barcelona technique in the application of implantable electric stimulators of anterior sacral roots (sars) for the control of sphincter’s dysfunction in spinal cord patients. Universitat Politècnica de Catalunya.

Bortole, M., Venkatakrishnan, A., Zhu, F., Moreno, J.C., Francisco, G.E., Pons, J.L. and Contreras-Vidal, J.L., The H2 robotic exoskeleton for gait rehabilitation after stroke: early findings from a clinical study, Journal of NeuroEngineering and Rehabilitation 2015, 12:54. DOI: 10.1186/s12984- 015-0048-y.

Cabib, C., Ortega, O., Kumru, H., Palomeras, E., Vilardell, N., AlvarezBerdugo, D., Muriana, D., Rofes, L., Terré, R., Mearin, F., Clavé, P., 2016. Neurorehabilitation strategies for poststroke oropharyngeal dysphagia: from compensation to the recovery of swallowing function. Ann. N. Y. Acad. Sci. 1380, 121–138. DOI:10.1111/nyas.13135

Claros, M.J., Soto, R., Gordillo, J.L., Pons, J.L. and Contreras-Vidal, J.L., Robotic Assistance of Human Motion using Active-backdrivability on a Geared Electromagnetic Motor, Int J Adv Robot Syst, 2016, 13:40. DOI: 10.5772/62331.

Corralejo, R., Hornero, R., Alvarez, D., 2011. Feature selection using a genetic algorithm in a motor imagery-based Brain Computer Interface. En 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 7703–7706. DOI: 10.1109/IEMBS.2011.6091898

Corralejo, R., Nicolas-Alonso L.F., Álvarez D., Hornero, R., 2014. A P300- based brain–computer interface aimed at operating electronic devices at home for severely disabled people. Medical and Biological Engineering and Computing, 52(10), 861–872. DOI: 10.1007/s11517-014-1191-5

Costa, A., Iáñez, E., Úbeda, A., Hortal, E., Del Ama, A., Gil, A.M., Azorin, J.M., 2016. Decoding the attentional demands of gait through EEG gamma band features. PLoS One 11(4), e0154136, 1 – 21.

Cullell, A., Moreno, J.C., Pons, J.L., Dynamic simulation of the behavior of an orthosis for knee and ankle functional compensation during gait, Gait and Posture, Vol. 26, SP-31 (2007).

Da Silva-Sauer L., Valero-Aguayo L., Velasco-Álvarez F., Ron-Angevin R., 2013. Psychological variables in the control of brain-computer interfaces. Psicothema 23(4), 745-751. Da Silva-Sauer, L., Valero-Aguayo, L., de la Torre-Luque, A., Ron-Angevin, R., Varona-Moya, S., 2016. Concentration on performance with P300- based BCI systems: A matter of interface features. Applied Ergonomics 52, 325-332. DOI: 10.1016/j.apergo.2015.08.002

de los Reyes-Guzmán, A., Dimbwadyo-Terrer, I., Pérez-Nombela, S., Monasterio-Huelin, F., Torricelli, D., Pons, J.L. and Gil-Agudo, A., 2016. Novel kinematic indices for quantifying upper limb ability and dexterity after cervical spinal cord injury, Med Biol Eng Comput, August 2016. DOI: 10.1007/s11517-016-1555-0

del Ama, A.J., Gil-Agudo, A., Bravo-Esteban, E., Pérez-Nombela, S., Pons, J.L., Moreno, J.C., 2014. Hybrid therapy of walking with Kinesis overground robot for persons with incomplete spinal cord injury: A feasibility study, Robotics and Autonomous Systems. DOI: 10.1016/j.robot.2014.10.014

DiGiovine, C. P., Bresler, M. I., Bahr, P. A., 2014. A Historical Overview of Rehabilitation Engineering. Proceedings of the Annual Conference of the Rehabilitation Engineering and Assistive Technology Society of North America. Indianapolis, USA, June 11-15, 2014.

Dosen, S., Muceli, S., Dideriksen, J.L., Romero, J.P., Rocon, E., Pons, J.L., Farina, D., Online Tremor Suppression using Electromyography and Low Level Electrical Stimulation, IEEE Trans. on Neural Systems and Rehabilitation Engineering 2014. DOI: 10.1109/TNSRE.2014.2328296

Duñabeitia, J.A., Ivaz, L., & Casaponsa, A., 2016. Developmental changes associated with cross-language similarity in bilingual children. Journal of Cognitive Psychology, 28:1, 16-31.

Escudero J., Sanei S., Jarchi D., Abásolo D., Hornero R., 2011. Regional coherence evaluation in mild cognitive impairment and Alzheimer's disease based on adaptively extracted magnetoencephalogram rhythms. Physiological Measurement, 32, 1163–1180.

Fernández, A., Zuluaga, P., Abásolo, D., Gómez, C., Serra, A., Méndez, M. A., Hornero, R., 2012. Brain oscillatory complexity across the life span. Clinical neurophysiology, 123 (11), 2154–2162.

Fernández-Rodríguez, A., Velasco-Álvarez, F., Ron-Angevin, R., 2016. Review of real brain-controlled wheelchairs. Journal of Neural Engineering 13(6). DOI: 10.1088/1741-2560/13/6/061001

Fraile, J. C., Pérez-Turiel, J., Baeyens, E., Viñas, P., Alonso, R., Cuadrado, A., Nieto, F., 2016. E2Rebot: A robotic platform for upper limb rehabilitation in patients with neuromotor disability. Advances in Mechanical Engineering, 8(8), 1-13. DOI: 10.1177/1687814016659050

Fraile, J.C., Pérez-Turiel, J., Viñas, P., Alonso, R., Cuadrado, A., Ayuso, L., García-Bravo, F., Nieto, F., Mihai, L., 2015. Control of the E2REBOT Platform for Upper Limb Rehabilitation in Patients with Neuromotor Impairment, Robot 2015: Second Iberian Robotics Conference, Volume 418 of the series Advances in Intelligent Systems and Computing, 303- 314. DOI 10.1007/978-3-319-27149-1_24

Frizera, A., Ceres, R., Pons, J.L., 2011. Filtrado Adaptativo de Componentes Involuntarias en Marcha Asistida por Andador para Detección de Intenciones. Revista Iberoamericana de Automática e Informática Industrial RIAI, 8, 71-80.

Gallego, J.A., Rocon, E., Belda, J.M., Pons, J.L., A Neuroprosthesis for Tremor Management through the Control of Muscle Co-contraction, Journal of NeuroEngineering and Rehabilitation 2013, 10:36.

Gómez, C., Olde Dubbelink, K.T., Stam, C.J., Abásolo, D., Berendse, H.W., Hornero, R., 2011. Complexity analysis of resting-state MEG activity in early-stage Parkinson's disease patients. Annals of Biomedical Engineering, 39(12), 2935-2944. DOI: 10.1007/s10439-011-0416-0

Gómez, C., Pérez-Macías, J. M., Poza, J., Fernández, A., Hornero, R., 2013. Spectral changes in spontaneous MEG activity across the lifespan. Journal of neural engineering, 10 (6), 066006.

Gomez-Pilar, J., Martín-Santiago, O., Suazo, V., Azua, S. R., Haidar, M. K., Gallardo, R., Poza, J., Hornero, R., Molina, V., 2016. Association between electroencephalographic modulation, psychotic-like experiences and cognitive performance in the general population. Psychiatry and clinical neurosciences.

Gonzalez-Moreno A., Aurtenetxe S., Lopez-Garcia M.E., del Pozo F., Maestu F., Nevado A., 2014. Signal-to-noise ratio of the MEG signal after preprocessing. J. Neurosci. Methods. 222:56-61.

Guerrero, C. R., Fraile, J. C., Pérez-Turiel, J., Farina, P. R., 2011. Robot biocooperativo con modulación háptica para tareas de neurorehabilitación de los miembros superiores. Revista Iberoamericana de Automática e Informática Industrial RIAI, 8(2), 63-70. DOI: 10.4995/RIAI.2011.02.09

Guerrero, C. R., Marinero, J. C. F., Turiel, J. P., Muñoz, V., 2013. Using “human state aware” robots to enhance physical human–robot interaction in a cooperative scenario. Computer methods and programs in biomedicine, 112(2), 250-259. DOI: 10.1016 / j.cmpb.2013.02.003

Guerrero, C. R., Marinero, J. F., Turiel, J. P., Farina, P. R., 2010. Bio cooperative robotic platform for motor function recovery of the upper limb after stroke. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology, 4472-4475. DOI: 10.1109/IEMBS.2010.5626052

Guillaume D; A Van HAvenbergh; Michael Vloeberghs; Joan Vidal; Geir Roeste. A clinical study of intrathecal baclofen using a programmable pump for intractable spasticity. Arch Phys Med Rehabil. 86, pp. 2165 – 2171. 2005.

Gunduz, A., Kumru, H., Pascual-Leone, A., 2014. Outcomes in spasticity after repetitive transcranial magnetic and transcranial direct current stimulations. Neural Regen. Res. 9, 712–718. DOI:10.4103/1673- 5374.131574

Hansen, L.B., Macizo, P., Duñabeitia, J.A., Saldaña, D., Carreiras, M., Fuentes, L.J., & Bajo, M.T., 2016. Emergent bilingualism and Working Memory development in school aged children. Lang. Learn., 66(2), 51-75.

Hayashibe, M., Guiraud, D., Pons, J.L. and Farina, D., Biosignal processing and computational methods to enhance sensory motor neuroprosthetics, Front. Neurosci. DOI: 10.3389/fnins.2015.004344

Hortal, E., Planelles, D., Costa, A., Iáñez, E., Úbeda, A., Azorín, J. M., Fernández, E., 2015a. SVM-based Brain-Machine Interface based on four mental tasks for controlling a robot arm. Neurocomp. 151(1), 116 - 121.

Hortal, E., Planelles, D., Resquín, F., Climent, J.M., Azorin, J.M., Pons, J.L, 2015b. Using a brain-machine interface to control a hybrid upper limb exoskeleton during rehabilitation of patients with neurological conditions. Journal of NeuroEngineering and Rehabilitation 12(92), 1-16. DOI: 10.1186/s12984-015-0082-9

Hortal, E., Úbeda, A., Iáñez, E., Azorín, J.M., 2014. Control of a 2 DoF Robot Using a Brain-Machine Interface. Computer Methods and Programs in Biomedicine 116(2), 169-176.

Hortal, E., Ubeda, A., Iañez, E., Azorin, J.M., Fernandez, E., 2016. EEGbased Detection of Starting and Stopping During Gait Cycle. International Journal of Neural Systems 26(7): 1650029, 1-13.

Ibáñez, J., Serrano, J.I., del Castillo, M.D., Minguez, J., Pons, J.L., 2015. Predictive classification of self-paced upper-limb analytical movements with EEG, Medical & Biological Engineering & Computing. DOI: 10.1007/s11517-015-1311-x

Koutsou, A., Moreno, J.C., del Ama, A.J., Rocon, E., Pons, J.L., Advances in Selective Activation of Muscles for Non-invasive Motor Neuroprostheses, Journal of NeuroEngineering and Rehabilitation, 2016, 13:56. DOI: 10.1186/s12984-016-0165-2

Kumru, H., Benito-Penalva, J., Valls-Sole, J., Murillo, N., Tormos, J.M., Flores, C., Vidal, J., 2016. Placebo-controlled study of rTMS combined with Lokomat(®) gait training for treatment in subjects with motor incomplete spinal cord injury. Exp. Brain Res. 234, 3447–3455. DOI:10.1007/s00221-016-4739-9

Kumru, H., Murillo, N., Samso, J.V., Valls-Sole, J., Edwards, D., Pelayo, R., Valero-Cabre, A., Tormos, J.M., Pascual-Leone, A., 2010. Reduction of spasticity with repetitive transcranial magnetic stimulation in patients with spinal cord injury. Neurorehabil. Neural Repair 24, 435–441. DOI:10.1177/1545968309356095

Lagoda, C., Moreno, J.C., Pons, J.L., Human-robot interfaces in exoskeletons for gait training after stroke: State of the art and challenges, Applied Bionics and Biomechanics 2012. DOI: 10.3233/ABB-2012-0056

Lambrecht, S., Gallego, J.A., Rocon, E., Pons, J.L., Automatic real-time monitoring and assessment of tremor parameters in the upper limb from orientation data, Front. Neurosci., 8: 221 (July, 24th, 2014). DOI: 10.3389/fnins.2014.00221

Lambrecht, S., Nogueira, S.L., Bortole, M., Siqueira A.A.G., Terra, M.H., Rocon, E., Pons, J.L., Inertial sensor error reduction through calibration and sensor fusión, Sensors 2016, 16, 235. DOI: 10.3390/s16020235

López M. E., Cuesta P., Garcés P., Castellanos P.N., Aurtenetxe S., Bajo R., Marcos A., Delgado M.L., Montejo P., López-Pantoja J.L., Maestú F., Fernandez A., 2014. MEG spectral analysis in subtypes of mild cognitive impairment. Age (Dordr). 36(3):9624.

Lopez-Gordo, M. A., Grima Murcia, M. D., Padilla P., Pelayo, F., Fernandez, E., 2016a. Asynchronous Detection of Trials Onset from Raw EEG Signals. International Journal of Neural Systems, 26 (7), 1–11.

Lopez-Gordo, M. A., Padilla P., Pelayo Valle, F., 2016b. A proposal for biosynchronized transmission of EEG/ERP data. Eurasip Journal on Wireless Communications and Networking, 54 (1), 1–12.

Lopez-Gordo, M. A., Padilla P., Pelayo, F., Fernandez, E., 2015. Asynchronous EEG/ERP acquisition for EEG teleservices. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 9107, 296–304.

Lopez-Gordo, M. A., Pelayo, F., Prieto, A., Fernandez, E., 2012. An auditory brain-computer interface with accuracy prediction. International Journal of Neural Systems, 22 (3), 1–14.

Lopez-Gordo, M. A., Prieto, A., Pelayo, F., Morillas, C., 2011a. Customized stimulation enhances performance of independent binary SSVEP-BCIs. Clinical Neurophysiology, 122 (1), 128–133.

Lopez-Gordo, M. A., Ron-Angevin, R., Pelayo Valle, F., 2011b. Auditory brain-computer interfaces for complete locked-in patients. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 6691 LNCS (PART 1), 378–385.

Lubeiro, A., Gomez-Pilar, J., Martín, O., Palomino, A., Fernández, M., González-Pinto, A., Poza, J., Hornero, R., Molina, V., 2015. Variation at NRG1 genotype related to modulation of small-world properties of the functional cortical network. European archives of psychiatry and clinical neuroscience, 1–8, Aceptado (no publicado).

Martin, P.I., Treglia, E., Naeser, M.A., Ho, M.D., Baker, E.H., Martin, E.G., Bashir, S., Pascual-Leone, A., 2014. Language improvements after TMS plus modified CILT: Pilot, open-protocol study with two, chronic nonfluent aphasia cases. Restor. Neurol. Neurosci. 32, 483–505. DOI:10.3233/RNN-130365

Martínez-Cagigal, V., Gomez-Pilar J., Álvarez D., Hornero, R., 2016. An Asynchronous P300-Based Brain-Computer Interface Web Browser for Severely Disabled People. IEEE Transactions on Neural Systems and Rehabilitation Engineering, Aceptado (no publicado). DOI: 10.1109/TNSRE.2016.2623381

Martínez-Cagigal, V., Núñez, P., Hornero, R., 2017. Spectral Regression Kernel Discriminant Analysis for P300 Speller Based Brain-Computer Interfaces. En Converging Clinical and Eng. Research on Neurorehab. II. Springer, 789–793. DOI: 10.1007/978-3-319-46669-9-129.

Martínez-Zarzuela, M., Gómez, C., Díaz-Pernas, F. J., Fernández, A., Hornero, R., 2013. Cross-approximate entropy parallel computation on GPUs for biomedical signal analysis. Application to MEG recordings. Computer methods and programs in biomedicine, 112 (1), 189–199.

Migliorelli, C, Alonso, J.F., Romero, S., Mañanas, M.A., Nowak, R., Russi, A. 2016. Influence of Metallic Artifact Filtering on MEG Signals for Source Localization during Interictal Epileptiform Activity. Journal of Neural Engineering 13 (2): 26029. DOI:10.1088/1741-2560/13/2/026029

Migliorelli, C, Alonso, J.F., Romero, S., Mañanas, M.A., Nowak, R., Russi, A. 2017. Visual Detection of High Frequency Oscillations in MEG. In, 769–73. Springer International Publishing. DOI: 10.1007/978-3-319- 46669-9_126.

Minguillon, J., Lopez-Gordo, M. A., Pelayo, F., 2016a. Detection of attention in multi-talker scenarios: A fuzzy approach. Expert Systems with Applications, 64 (DEC), 261–268.

Minguillon, J., Lopez-Gordo, M. A., Pelayo, F., 2016b. Stress assessment by prefrontal relative gamma. Frontiers in Computational Neuroscience, 10 (SEP), 101.

Minguillon, J., Lopez-Gordo, M. A., Pelayo, F., 2017. Trends in EEG-BCI for daily-life: Requirements for artifact removal. Biomedical Signal Processing and Control, 31 (JAN), 407–418. DOI: 10.1016/j.bspc.2016.09.005

Moreno, J.C., Brunetti, F., Rocon, E., Pons, J.L., Immediate effects of a controllable knee ankle foot orthosis for functional compensation of gait in patients with proximal leg weakness, Medical Biological Engineering & Computing., 46-1, pp. 43-53, 2008.

Moreno, J.C., Brunetti, F.J., Cullell, A., Forner-Cordero, A., Pons, J.L., Simulation of knee function during gait with an orthosis by means of two springs of different stiffnesses, Gait and Posture, Vol. 21, pp. S140 (2005).

Moreno, J.C., Rocon, E., Ruiz, A.F., Brunetti, F., Pons, J.L., Design and implementation of an inertial measurement unit for control of artificial limbs: application on leg orthoses, Sensors and Actuators B, 118, pp. 333- 337 (2006).

Nicolas-Alonso, L.F., Corralejo R., Gomez-Pilar J., Álvarez D., Hornero R., 2015. Adaptive semi-supervised classification to reduce intersession nonstationarity in multiclass motor imagery-based brain–computer interfaces. Neurocomputing, 159, 186–196. DOI: 10.1016/j.neucom.2015.02.005

Opisso, E., Borau, A., Rijkhoff, N.J.M., 2011. Urethral sphincter EMGcontrolled dorsal penile/clitoral nerve stimulation to treat neurogenic detrusor overactivity. J. Neural Eng. 8, 036001. DOI:10.1088/1741- 2560/8/3/036001

Opisso, E., Borau, A., Rijkhoff, N.J.M., 2013. Subject-controlled stimulation of dorsal genital nerve to treat neurogenic detrusor overactivity at home. Neurourol. Urodyn. 32, 1004–1009. DOI:10.1002/nau.22359

Pérez-Nombela, S., Barroso, F., Torricelli, D., de los Reyes-Guzmán, A., del Ama-Espinosa, A.J., Gomez-Soriano, J., Pons, J.L., and Gil-Agudo, A., Modular control of gait after Incomplete Spinal Cord Injury: differences between sides, Spinal Cord, (28 June 2016). DOI: 10.1038/sc.2016.99

Piazza, S., Gomez-Soriano, J., Bravo-Esteban, E, Torrecelli, D., Avíla-Martín, G., Galan-Arriero, I, Pons, J.L.; Taylor, J., Maintenance of cutaneomuscular neuronal excitability after leg-cycling predicts lower limb muscle strength after incomplete spinal cord injury, Clinical Neurophysiology 127 (2016) 2402–2409. DOI: 10.1016/j.clinph.2016.03.007

Pons, J.L., Rehabilitation Exoskeletal Robotics, IEEE Engineering in Medicine and Biology Magazine, 29-3, pp. 57-63, 2010.

Rajasekaran, V., Aranda, J., Casals, A., Pons, J.L, 2014. An adaptive control strategy for postural stability using a wearable robot, Robotics and Autonomous Systems. DOI: 10.1016/j.robot.2014.11.014

Raya, R., Roa, J.O., Rocon, E., Ceres, R., Pons, J.L., Wearable inertial mouse for children with physical and cognitive impairments, Sensors & Actuators: Physical, 162(2), August 2010, pp. 248-259, 2010.

Renedo-Criado, D. A., López-Gordo, M. A., Minguillón, J., Sánchez-Carrión M. J., Pelayo, F., 2016. Electrophysiological measurement of effects of color over level of stress. 4th International Work-Conference on Bioinformatics and Biomedical Engineering (IWBBIO) 2016, Granada (Spain), April 2016.

Resquín, F., Gonzalez-Vargas, J., Ibáñez, J., Brunetti, F., Pons, J.L., Feedback error learning controller for functional electrical stimulation assistance in a hybrid robotic system for reaching rehabilitation, European Journal of Translational Myology 26, 3 (2016). DOI: 10.4081/ejtm.2016.6164

Rocon, E., Belda-Lois, J.M., Ruiz, A.F., Manto, M., Pons, J.L., 2007. Design and Validation of a Rehabilitation Robotic Exoskeleton for Tremor Assessment and Suppression, IEEE Transactions on Neural Systems and Rehabilitation Engineering, 15-3, pp. 367-378.

Rodriguez-Ugarte, M., Sciacca, N., Azorín, J.M., 2016. Transcranial Direct Current Stimulation (tDCS) and transcranial Current Alternating Stimulation (tACS) review. En: Actas de las XXXVII Jornadas de Automática (7, 8 y 9 de septiembre de 2016, Madrid), 137 -143.

Roig Rovira, T., García Molina, A., Pascual Leone, A., Castaño Monsalve, B., Soler Fernandez, D., Tormos Muñoz, J.M., Bernabeu Guitart, M., Fecteau, S., Robles, V., 2010. Eficacia de la estimulación directa transcraneal en el tratamiento de la apatía secundaria a lesiones cerebrales de origen traumático. Fund. Mapfre.

Romero S., Mañanas M.A., Barbanoj M.J., 2009a. Ocular reduction in EEG signals based on adaptive filtering, regression and blind source separation, Annals of Biomedical Engineering, 37 (1), 176-191. DOI: 10.1007/s10439- 008-9589-6

Romero S., Mañanas M.A., Barbanoj M.J., 2009b. Influence of ocular filtering in EEG data on the assessment of drug-induced effects on the brain, Human Brain Mapping, 30(5), 1470-1480. DOI:10.1002/hbm.20614

Ron-Angevin, R., Díaz-Estrella, A, Velasco-Álvarez, F., 2009b. A two-class Brain-Computer Interface to freely navigate through virtual worlds. Biomedizinische Technik 54, 126-133. DOI: 10.1515/BMT.2009.014

Ron-Angevin, R., Diaz-Estrella, A., 2008. Training protocol evaluation of a brain-computer interface: mental tasks proposal. Revista de neurología 47(4), 197-203.

Ron-Angevin, R., Díaz-Estrella, A., 2009a. Brain-computer interface: Changes in performance using virtual reality techniques. Neuroscience letters 449 (2), 123-127. DOI: 10.1016/j.neulet.2008.10.099

Ron-Angevin,R., Varona-Moya, S., da Silva-Sauer, L., 2015. Initial test of a T9-like P300-based speller by an ALS patient. Journal of Neural Engineering 12(4). DOI: 10.1088/1741-2560/12/4/046023

Rosset-Llobet, J., Fàbregas-Molas, S., Pascual-Leone, Á., 2015. Effect of Transcranial Direct Current Stimulation on Neurorehabilitation of TaskSpecific Dystonia: A Double-Blind, Randomized Clinical Trial. Med. Probl. Perform. Art. 30, 178–184.

Salazar-Varas, R. Costa, A., Iáñez, E., Úbeda, A., Hortal, E., Azorín, J.M., 2015. Analyzing EEG signals to detect unexpected obstacles during walking. Journal of NeuroEngineering and Rehabilitation 12(101), 1-15.

Sarrias, M., Sarrias, F., Borau, A., 1993. The “Barcelona” technique. Neurourol. Urodyn. 12, 495–496.

Serrano, J., Del Castillo, M., Raya, R., Bayón, C., Martínez Caballero, I., Lerma, S., Rocon, E., 2015. BCI basado en la facilitación asociativa de la actividad cortical para el inicio de la marcha en Parálisis Cerebral. Cognitive Area Networks 2(1), 23-26.

Sirvent Blasco, J.L., Iáñez, E., Úbeda, A., Azorín, J.M., 2012. Visual evoked potential-based brain-machine interface applications to assist disabled people. Expert Systems with Applications 39(9), 7908- 7918.

Slabu, L.M., Escera, C., Grimm, S., & Costa-Faidella, J., 2010. Early change detection in humans as revealed by auditory brainstem and middle-latency evoked potentials. European Journal of Neuroscience, 32, 859-865.

Slof, J., Serrano, D., Álvarez, M., Álvarez López-Dóriga, M., Marqués, T., Benito, J., Vidal, J., 2014. Cost-Effectiveness Model Results of Intrathecal Baclofen Therapy Compared to Conventional Medical Management in Patients with Non-Focal Disabling Spasticity Who Are Resistant or Intolerant to Oral Therapy at the Institut Guttmann. Value Health J. Int. Soc. Pharmacoeconomics Outcomes Res. 17, A399-400. DOI: 10.1016/j.jval.2014.08.907

Solé-Casals, J., Vialatte, F.B., 2015. Towards Semi-Automatic Artifact Rejection for the Improvement of Alzheimer’s Disease Screening from EEG Signals, Sensors, 15(8), 17963-17976. DOI: 10.3390/s150817963

Soler, M.D., Kumru, H., Pelayo, R., Vidal, J., Tormos, J.M., Fregni, F., Navarro, X., Pascual-Leone, A., 2010. Effectiveness of transcranial direct current stimulation and visual illusion on neuropathic pain in spinal cord injury. Brain J. Neurol. 133, 2565–2577. DOI:10.1093/brain/awq184

Torricelli, D., Gonzalez, J., Weckx, M., Jiménez-Fabián, R., Vanderborght, B., Sartori, M., Dosen, S., Farina, D., Lefeber, D., Pons, J.L., 2016. Human-like compliant locomotion: State of the art of robotic implementations, Bioinspiration & Biomimetics, 11, 051002. DOI: 10.1088/1748-3190/11/5/051002

Tran, D., Pajaro-Blazquez, M., Daneault, J.C., Gallegos, J.G., Pons, J.L., Fregni, F., Bonato, P., Zafonte, R., The case for combining dopaminergic facilitation with robot-assisted upper-limb therapy in stroke survivors: a position paper, American J. of PM&R, January 29, 2016. DOI: 10.1097/PHM.0000000000000438

Úbeda, A., Hortal, E., Iáñez, E., Pérez-Vidal, C., Azorin, J.M., 2015. Assessing Movement Factors in Upper Limb Kinematics Decoding from EEG Signals. PLoS One 10(5), e0128456, 1 – 12.

Varona-Moya, S., Velasco-Álvarez, F., Sancha-Ros, S., FernándezRodríguez,A., Blanca-Mena, M.J., Ron-Angevin, R., 2015. Wheelchair Navigation with an Audio-cued, Two-Class Motor Imagery-based Brain– Computer Interface System. Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering. DOI: 10.1109/NER.2015.7146588

Velasco-Álvarez F., Ron-Angevín R., Blanca-Mena M.J., 2010. Free Virtual Navigation Using Motor Imagery Through an Asynchronous BrainComputer Interface. Presence, Teleoperators and Virtual Environments 19 (1), 71-81. DOI: 10.1162/pres.19.1.71

Velasco-Álvarez, F., Ron-Angevin, R., da Silva-Sauer, L., Sancha-Ros, S., 2013. Audio-cued motor imagery-based brain-computer interface: Navigation through virtual and real environments. Neurocomputing 121(9), 89-98. DOI: 10.1016/j.neucom.2012.11.038

Vialatte, F.B., Solé-Casals, J., Cichocki, A., 2008. EEG Windowed Statistical wavelet scoring for evaluation and discrimination of muscular artifacts, Physiol. Meas. 29, 1435-1452.

Vidal J; Fenollosa P; E Martin; j Barbera; FJ Robaina; M Fuentes; M Rodriguez; C Arechaga; ML Franco; E Rodriguez. 2000. Safety and efficacy of intrathecal baclofen infusion by implantable pump for the treatment of severe spinal spasticity: A Spanish Multicenter study. Neuromodulation. 3 - 4, pp. 175 - 182

Vidal, J., Slof, J., Serrano, D., Marqués, T., Kumru, H., Benito-Penalva, J., 2016. Cost-effectiveness of Intrathecal Baclofen Therapy in severe refractory non-focal disabling spasticity: A Spanish hospital perspective. Expert Rev. Pharmacoecon. Outcomes Res. 1–10. DOI:10.1080/14737167.2016.1180247

Vidal-Piñeiro, D., Martin-Trias, P., Arenaza-Urquijo, E.M., Sala-Llonch, R., Clemente, I.C., Mena-Sánchez, I., Bargalló, N., Falcón, C., Pascual-Leone, Á., Bartrés-Faz, D., 2014. Task-dependent activity and connectivity predict episodic memory network-based responses to brain stimulation in healthy aging. Brain Stimulat. 7, 287–296. DOI: 10.1016/j.brs.2013.12.016

Xu, R., Jiang, N., Mrachacz-Kersting, N., Lin, C., Asín, G., Moreno, J.C., Pons, J.L., Dremstrup, K., Farina, D., A Closed-Loop Brain-Computer Interface Triggering an Active Ankle-Foot Orthosis for Inducing Cortical Neural Plasticity, IEEE Trans. on Biomedical Engineering 2014, 61(7), pp. 2092-2101. DOI: 10.1109/TBME.2014.2313867

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