Avaliaçao do risco toxicológico de misturas complexas através do Modelo WTox

William Gerson Matias, Letícia Flohr

Resumen

Modelos matemáticos sao importantes ferramentas de gestão ambiental e gerenciamento de riscos. Previsões sobre toxicidade de misturas químicas ainda devem ser aprimoradas, devido à complexidade de efeitos que podem causar aos seres vivos. Neste trabalho, avaliou-se risco ambiental abordando a necessidade do estudo da relação entre organismo e xenobióticos. Para isto, cinco tipos de testes toxicológicos foram aplicados através do Modelo WTox, e com esta metodologia foi possível obter a classificação do risco de substâncias potencialmente ttóxicas. Toxicidade aguda, crônica, citotoxicidade e genotoxicidade foram observadas nos organismos Daphnia magna, Vibrio scheri e Oreochromis niloticus. Um estudo de caso foi realizado com resíduos sólidos provenientes da indústria têxtil, metal-mecânica e de papel e celulose. Os resultados demonstraram que diversos resíduos induziram mortalidade, efeitos na reprodução, aumentos na taxa de lipoperoxidacao, mutações e alterações na mutilação do DNA dos organismos. Estes resultados, analisados através do Modelo WTox, permitiram a classificação de risco ambiental dos resíduos industriais. A avaliacao classificou as amostras como de risco ambiental toxicológico significativo ou crítico.


Palabras clave

Modelo WTox; Risco ambiental; Ensaios toxicológicos; Misturas complexas

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