Adrenal weight and serum cholesterol concentration in rabbits with differential cholesterolaemic response to cholesterol feeding.
The question addressed is whether in rabbits a relationship exists between serum cholesterol response to dietary cholesterol and adrenals autopsy weight. For this purpose we have measured adrenals weight and serum cholesterol levels in backcross and F2-intercross progeny of a cross between IIIVO/JU (dietary cholesterol resistant) and AX/JU (dietary cholesterol susceptible) rabbits. The animals were fed a commercial, pelleted diet enriched with 0.3% (w/w) cholesterol during a test period which lasted 41 (backcross rabbits) or 78 (F2-intercross rabbits) days. After the test period hyperresponders with high serum cholesterol levels and hyporesponders with low serum cholesterol levels could be distinguished from normoresponders, both within backcross and F2-intercross rabbits. A positive relationship between serum cholesterol response and adrenals weight was found for male, but not for female F2-intercross rabbits. No clear dose-response relationship between serum cholesterol response and adrenals weight was found both for male and female backcross rabbits. It is concluded that the relationship between serum cholesterol response and adrenals weight in rabbits is certainly not a simple one and may depend on gender, duration of the experimental period and the genetic background of the animals.
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